The Combination of Metformin and Disulfiram-Cu for Effective Radiosensitization on Glioblastoma Cells.

Abstract

It seems that the synergistic application of both Met and DSF with the support of irradiation can remarkably restrict the growth of the U87-MG cell line. This may trigger apoptosis via the stimulation of the intrinsic pathway. The combinatory use of Met and DSF in the presence of irradiation could be applied for patients afflicted with GBM.