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Drug Synergism: Studies of Combination of RK-52 and Curcumin against Rhodesain of <i>Trypanosoma brucei rhodesiense</i>

Roberta Ettari, Santo Previti, Carla Di Chio, Santina Maiorana, Alessandro Allegra, Tanja Schirmeister, Maria Zappalà

ACS Medicinal Chemistry Letters · 2020 · 14 citations · 20 references

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Abstract

values, which means a potent synergistic effect for the reduction of rhodesain activity from 40% to 99%.

References

20

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

Ting‐Chao Chou, Paul Talalay · Advances in Enzyme Regulation · 1984 · 7.2K citations

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Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

Ting‐Chao Chou · Cancer Research · 2010 · 5.7K citations

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Human African trypanosomiasis

The Lancet · 2017 · 696 citations

Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial

Gérardo Priotto, S Kasparian, Wilfried Mutombo et al. · The Lancet · 2009 · 532 citations

, , +12

Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense

Conor R. Caffrey, Elizabeth Hansell, Kimberley D. Lucas et al. · Molecular and Biochemical Parasitology · 2001 · 179 citations

, , +15