Gold(I)‐Catalyzed Alkoxyhalogenation of β‐Hydroxy‐α,α‐Difluoroynones

Abstract

Gold standard: AuCl was found to be the only suitable catalyst for the 6-endo-dig ring closure of hydroxylated difluorinated ynones (see scheme), a class of substrates that displays low reactivity owing to the presence of the gem-difluoro group. For the first time, a gold catalyst is used in combination with an electrophilic fluorinating reagent. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z802162_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.