Gold(I)‐Catalyzed Alkoxyhalogenation of β‐Hydroxy‐α,α‐Difluoroynones

Abstract

Gold standard: AuCl was found to be the only suitable catalyst for the 6-endo-dig ring closure of hydroxylated difluorinated ynones (see scheme), a class of substrates that displays low reactivity owing to the presence of the gem-difluoro group. For the first time, a gold catalyst is used in combination with an electrophilic fluorinating reagent.