c-Jun Overexpression Accelerates Wound Healing in Diabetic Rats by Human Umbilical Cord-Derived Mesenchymal Stem Cells

Abstract

c-Jun overexpression promoted hUC-MSC proliferation and migration <i>in vitro</i> and accelerated diabetic wound closure, reepithelization, and angiogenesis by hUC-MSCs <i>in vivo</i>. These beneficial effects of c-Jun overexpression in diabetic wound healing by hUC-MSCs were at least partially mediated by increased PDGFA and HGF levels in wound tissues.