Impact of <i>GFRA1</i> gene reactivation by DNA demethylation on prognosis of patients with metastatic colon cancer

Abstract

<i>GFRA1</i> expression is frequently reactivated by DNA demethylation in CC tissues and is significantly associated with a poor prognosis in patients with CC, especially those with metastatic CC. GFRA1 can promote the proliferation/growth of CC cells, probably by the activation of AKT and ERK pathways. GFRA1 might be a therapeutic target for CC patients, especially those with metastatic potential.