<i>PSEN1, PSEN2</i>, and <i>APP</i> mutations in 404 Chinese pedigrees with familial Alzheimer's disease

Abstract

The new PSENs/APP mutations indicate heterogeneity in AD pathogenesis between Chinese and other ethnic groups. The low mutation rate suggests the involvement of other genes/factors in Chinese FAD. APOEε4 might be a major gene for some FAD without PSENs/APP mutations.