icacy during RT. This work thus presents a unique type of nanoscale RBC mimic for efficient oxygen delivery into solid tumors, favorable for cancer treatment by RT, and potentially other types of therapy as well.20:T527,Abstract A photothermally sensitive poly( N ‐isopropylacrylamide)/graphene oxide (PNIPAM/GO) nanocomposite hydrogel can be synthesized by in situ γ‐irradiation‐assisted polymerization of an aqueous solution of N ‐isopropylacrylamide monomer in the presence of graphene oxide (GO). The colors and phase‐transition temperatures of the PNIPAM/GO hydrogels change with different GO doping levels. Due to the high optical absorbance of the GO, the nanocomposite hydrogel shows excellent photothermal properties, where its phase transitions can be controlled remotely by near‐infrared (NIR) laser irradiation, and it is completely reversible via laser exposure or non‐exposure. With a higher GO loading, the NIR‐induced temperature of the nanocomposite hydrogel increases more quickly than with a lower doping level and the temperature can be tuned effectively by the irradiation time. The nanocomposite hydrogel with its excellent photothermal properties will have great applications in the biomedical field, especially as microfluidic devices; this has been demonstrated in our experiments by way of remote microvalves to control fluidic flow. Such an “easy” and “clean” synthetic procedure initiated by γ‐irradiation can be extended for the efficient synthesis of other nanocomposite materials.21:T452,Tumor hypoxia severely limits the efficacy of traditional photodynamic therapy (PDT). Here, a liposome-based nanoparticle (designated as LipoMB/CaO₂ ) with O₂ self-sufficient property for dual-stage light-driven PDT is demonstrated to address this problem. Through a short time irradiation, ¹ O₂ activated by the photosensitizer methylene blue (MB) can induce lipid peroxidation to break the liposome, and enlarge the contact area of CaO₂ with H₂ O, resulting in accelerated O₂ production. Accelerated O₂ level further regulates hypoxic tumor microenvironment and in turn improves ¹ O₂ generation by MB under another long time irradiation. In vitro and in vivo experiments also demonstrate the superior competence of LipoMB/CaO₂ to alleviate tumor hypoxia, suppress tumor growth and antitumor metastasis with low side-effect. The O₂ self-sufficient LipoMB/CaO₂ nanoplatform with dual-stage light manipulation is a successful attempt for PDT against hypoxic tumor.

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