Visible-Light-Promoted C2 Selective Arylation of Quinoline and Pyridine <i>N</i>-Oxides with Diaryliodonium Tetrafluoroborate

Abstract

A protocol of visible-light-promoted C2 selective arylation of quinoline and pyridine <i>N</i>-oxides, with diaryliodonium tetrafluoroborate as an arylation reagent, using eosin Y as a photocatalyst for the construction of <i>N</i>-heterobiaryls was presented. This methodology provided an efficient way for the synthesis of 2-aryl-substituted quinoline and pyridine <i>N</i>-oxides. This strategy has the following advantages: specific regioselectivity, simple operation, good functional group tolerance, and high to moderate yields under mild conditions.