Multiple NDM-5-Expressing Escherichia Coli Isolates From an Immunocompromised Pediatric Host

Abstract

We present unique microbiologic data from 33 multidrug-resistant <i>E. coli</i> isolates obtained over the course of 7 months from an individual patient in the United States. Two <i>E. coli</i> sequence types causing invasive infection in the same patient and harboring the blaNDM-5 gene, encoded on the IncX3 plasmid and the IncFII plasmid, were identified. This study highlights the emergence of multidrug-resistant bacteria on antibiotic therapy and the necessity of adequate neutrophil number and function in the clearance of bacteremia.