PubMed · 2018 · 10 citations · 0 references
Life SciencesPharmacologyPhysiologyCell SignalingMolecular PharmacologySignal TransductionAcid-base RegulationGastrointestinal FunctionGastrointestinal PathophysiologyGastrointestinal PharmacologyGastrointestinal PhysiologyIon Channel PharmacologyAcid Secretion InhibitionGastric Acid-base BalanceGastric Ph RegulationGastric SecretionNf-kappa B-dependent TranscriptionNf-κb SignalingNuclear Factor Kappa B SignalingSubstance P Pharmacology
) receptor antagonist; and PDTC, a NF-κB inhibitor. The data from these experiments suggest that NaHS exerts an excitatory effect on gastric acid secretion possibly mediated by TRPV1 channel activation in sensory nerve terminals with the consequent release of substance P and in a NF-κB -dependent manner.