Synthesis, DFT Calculation and Biological Activity of Some Organotellurium Compounds Containing Azomethine Group

Abstract

<p class="orbitalabstract">The reaction of (4-amino-2,3-dichlorophenyl)mercury (II) chloride with 3,4-dihydroxy benzaldehyde produce the organomercury compound <strong>1 </strong>in 82% yield. Tellurated of <strong>1</strong> with tellurium (IV) tetrabromide gave the tellurium (IV) tribromide Schiff base compound <strong>2</strong>. The reaction between <strong>1</strong> and <strong>2</strong> gave the diaryltelluride dibromide compound<strong> 4</strong>.<strong> </strong>Reduction of <strong>2 </strong>and<strong> 4 </strong>by hydrazine hydrate gave diaryal ditelluride <strong>3</strong> and diaryal telluride <strong>5</strong> respectively in 53% and 61% yields. All new compounds were characterized by FT-IR, NMR and mass spectroscopy. The geometry optimization of molecular structure and energies was calculated using density functional theory by Material studio-DMol3 program. The synthesized compounds were screened for their antibacterial activity against Escherichia coli, Pseudomonas spp., Klebsiella pneumonia, Proteus and Staphylococcus aureus. <strong> </strong>Additionally, the compounds were tested as antioxidant activity by DPPH(1,1-Diphenyl-2-picryl-hydrazyl) assay method. The compounds exhibited its have antibacterial and antioxidant activity, and the compounds <strong>2</strong> and <strong>4</strong> gave higher activity than other compounds. <p class="orbitalabstract"> <p class="orbitalabstract">DOI: <a href="http://dx.doi.org/10.17807/orbital.v11i7.1211">http://dx.doi.org/10.17807/orbital.v11i7.1211</a>