BUB1B Promotes Proliferation of Prostate Cancer via Transcriptional Regulation of MELK

Abstract

Altogether, our data suggest that BUB1B is up-regulated in prostate cancer, suggesting that the growth of cancer cells may depend on BUB1B-dependent regulation of MELK transcription. BUB1B may serve as a clinical prognostic factor and a druggable target for prostate cancer.