Biomaterials Science · 2020 · 12 citations · 41 references
Life SciencesBioengineeringBiomedical EngineeringBiomaterialsCell AdhesionCell SignalingBiomaterials For Tissue EngineeringCell-matrix AdhesionCell-scaffold InteractionsCollagen-based BiomaterialsExtracellular MatrixTissue Engineering ScaffoldsCell Adhesion To CollagenCell-matrix Adhesion MechanicsCell-matrix Adhesion SignalingCollagen Fibril OrganizationCollagen GelsCollagen NetworksCollagen-based NanomaterialsLaminin Binding
Cells respond to biophysical and biochemical signals. We developed a composite filament from collagen and silica particles modified to interact with collagen and/or present a laminin epitope (IKVAV) crucial for cell-matrix adhesion and signal transduction. This combines scaffolding and signaling and shows that local tuning of collagen organization enhances cell differentiation.
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Selective Differentiation of Neural Progenitor Cells by High-Epitope Density Nanofibers
Gabriel A. Silva, Catherine Czeisler, Krista L. Niece et al. · Science · 2004 · 2.2K citations