New England Journal of Medicine · 2019 · 243 citations · 15 references
Veterinary MedicineInfectious Disease ControlInfectious DiseasesEpidemiologyGlobal HealthParasitologyDisease ControlHelminth ControlMedical ParasitologyParasite ControlParasitic Disease PreventionSurveillance Of Parasitic DiseasesMedical HelminthologyParasitic Infection PreventionSchistosomiasis Treatment
BACKGROUND: With the vision of "a world free of schistosomiasis," the World Health Organization (WHO) set ambitious goals of control of this debilitating disease and its elimination as a public health problem by 2020 and 2025, respectively. As these milestones become imminent, and if programs are to succeed, it is important to evaluate the WHO programmatic guidelines empirically. METHODS: infection. RESULTS: infection (in Burkina Faso, Burundi, and Rwanda within three treatment rounds). Intracountry variation was evident in the relationships between overall prevalence and heavy-intensity infection (stratified according to treatment rounds), a finding that highlights the challenges of using one metric to define control or elimination across all epidemiologic settings. CONCLUSIONS: These data suggest the need to reevaluate progress and treatment strategies in national schistosomiasis control programs more frequently, with local epidemiologic data taken into consideration, in order to determine the treatment effect and appropriate resource allocations and move closer to achieving the global goals. (Funded by the Children's Investment Fund Foundation and others.).
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