Controlled delivery of ciprofloxacin and ivacaftor via sinus stent in a preclinical model of <i>Pseudomonas</i> sinusitis

Abstract

The CISS had robust clinical efficacy in treating P aeruginosa rabbit sinusitis. The innovative design of double-layered drug coating on the surface of the biodegradable stent may provide therapeutic advantages over current treatment strategies for P aeruginosa sinusitis.