Comparative Biochemical Outcomes, Effectiveness and Tolerance of Densiron 68 and Oxane HD for the Management of Complicated Retinal Detachment

Abstract

Objectives: To compare biochemical outcomes, effectiveness, and tolerance of two high-density silicone oils (HDSOs), silicone oil-RMN3 (Oxane HD) and silicone oil-Densiron-68 (Densiron 68), for the management of complicated retinal detachment (RD) associated with inferior proliferative vitreoretinopathy (PVR). Materials and Methods: This was a retrospective, single-centre, comparative case series of 23 patients treated between September 2014 and June 2016. The main inclusion criteria were RD with inferior PVR receiving Oxane HD or Densiron 68 following pars plana vitrectomy. The main outcome measures were anatomical success, rate of RD recurrence, and best-corrected visual acuity (BCVA) at 6 months. Secondary outcomes were short-term complications. Results: Twenty-three eyes were included: 16 eyes with Densiron 68 tamponade and 7 eyes with Oxane HD tamponade. Anatomical success under HDSO was significantly higher in the Densiron 68 group (100%) than in the Oxane HD group (42.8%) (p=0.0455). Recurrent RD was observed in 42.8% of eyes under Oxane HD, but in none of the patients under Densiron 68 (p=0.001). Six months after surgery, mean BVCA values (+/-standard deviation) with Densiron 68 and Oxane HD were 0.830.62 logMAR and 1.810.65 logMAR, respectively. BVCA was significantly better in the Densiron 68 group (p=0.006). No significant differences were observed with regard to intraocular pressure, emulsification, or intraocular inflammation. Conclusion: Densiron 68 appears to be more effective than Oxane HD for the management of RD associated with PVR. A randomized, controlled, interventional study is needed to demonstrate this difference.