Anticancer Research · 2019 · 44 citations · 27 references
MedicineOncologyRadiation OncologyChemotherapySurgical OncologyTreatment PlanningCancer Survival AnalysisPancreatic CancerRadiation TherapyRadiobiological ConsiderationsCox RegressionDistant Metastasis-free SurvivalDistant Nodal MetastasisKaplan-meier Confidence IntervalsLocal Control AssessmentOncologic Outcomes AssessmentPancreatic Cancer RadiotherapyStereotactic Body Radiotherapy Dosimetry
Aim: The purpose of the present multicentric study was to review stereotactic body radiotherapy (SBRT) with or without chemotherapy (CHT) experience in locally advanced pancreatic cancer (LAPC). Endpoints were overall survival (OS), local control (LC), and distant metastasis-free survival (DMFS). Several parameters9 impact on these outcomes was assessed. Materials and Methods: Fifty-six patients with LAPC undergoing SBRT+/-CHT were included. SBRT median BED<sub>α/β10Gy</sub> was 48.0 Gy (range=28.0-78.7). Survival curves were calculated by Kaplan-Meier method. A Cox regression model was fitted. Results: At a median follow-up of 15.0 months, 2-year OS, LC, DMFS were: 33.8% 55.4%, and 22.9%, respectively. Patients treated with BED<sub>α/β10Gy</sub>≥48 Gy showed improved OS (p=0.020) and LC (p=0.024). At multivariate analysis, BED<sub>α/β10Gy</sub>≥48 Gy was significantly associated to both higher OS (p=0.042) and LC (p=0.045), while post-SBRT CHT improved DMFS (p=0.003). Conclusion: SBRT proved to be tolerable and effective in LAPC. Moreover, BED<sub>α/β10Gy</sub>≥48 Gy was significantly correlated with improved OS and LC.
27
Rebecca L. Siegel, Kimberly D. Miller, Ahmedin Jemal · CA A Cancer Journal for Clinicians · 2018 · 17K citations · Full text