Synthesis of 1,2-amino alcohols by decarboxylative coupling of amino acid derived α-amino radicals to carbonyl compounds <i>via</i> visible-light photocatalyst in water

Abstract

A general and efficient visible-light photoredox-catalyzed decarboxylative radical coupling reaction of <italic>N</italic>-aryl amino acids with aldehydes or ketones for the synthesis of 1,2-amino alcohols in water at room temperature is described.