High doses of memantine (1-amino-3,5-dimethyladamantane) induce seizures in kindled but not in non-kindled rats

Modification of seizure activity by electrical stimulation: II. Motor seizure

Ronald J. Racine · Electroencephalography and Clinical Neurophysiology · 1972 · 7.2K citations

Stimulation Device, Electrical Stimulation, Neurophysiology +14

NMDA receptors of dentate gyrus granule cells participate in synaptic transmission following kindling

István Módy, Uwe Heinemann · Nature · 1987 · 395 citations

Synaptic Plasticity, Neurophysiology, Neuroanatomy +8

Memantine is a potent blocker of N-methyl-D-aspartate (NMDA) receptor channels

Joachim Bormann · European Journal of Pharmacology · 1989 · 352 citations

Molecular Physiology, Biochemistry, Functional Selectivity +8

Anticonvulsant drugs: mechanisms of action.

Robert L. Macdonald, Michael J. McLean · PubMed · 1986 · 227 citations

Synaptic Transmission, Neurotransmitter, Psychopharmacology +18

Rapid Changes in Brain Benzodiazepine Receptors After Experimental Seizures

Steven M. Paul, Phil Skolnick · Science · 1978 · 195 citations

Brain Benzodiazepine Receptors, Receptor Affinity, Neurophysiology +14