Extragonadal Steroids Contribute Significantly to Androgen Receptor Activity and Development of Castration Resistance in Recurrent Prostate Cancer after Primary Therapy - Concepedia

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Extragonadal Steroids Contribute Significantly to Androgen Receptor Activity and Development of Castration Resistance in Recurrent Prostate Cancer after Primary Therapy

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References

2019

Year

Frédéric Pouliot, Mélanie Rouleau, Bertrand Neveu, Paul Toren, Fannie Morin, Lauriane Vélot, Keyue Ding, Patrick Caron, Louis Lacombe, Éric Lévesque,

The Journal of Urology

Abstract

Extragonadal steroids contribute significantly to the androgen receptor axis activation at castration levels of testosterone in recurrent nonmetastatic prostate cancer and these sustain the development of castration resistance after primary local treatment.