Impact of Candida auris Infection in a Neutropenic Murine Model

Abstract

<i>Candida auris</i> has become a global public health threat due to its multidrug resistance and persistence. Currently, there are limited murine models to study <i>C. auris</i> infection. Those models use a combination of cyclophosphamide and cortisone acetate, suppressing both innate and adaptive immunity. Here, we compare <i>C. auris</i> infection in two neutrophil-depleted murine models in which innate immunity is targeted using the monoclonal antibodies 1A8 and RB6-8C5.