Adipocytes promote interleukin-18 binding to its receptors during abdominal aortic aneurysm formation in mice

Abstract

Interleukin-18 uses both IL18r and NCC to promote AAA formation. Lesion adipocyte and perivascular adipose tissue contribute to AAA pathogenesis by releasing leptin and FABP4 that induce IL18, IL18r, and NCC expression and promote IL18 actions.