Antifungal Sesquiterpenoids, Rhodocoranes, from Submerged Cultures of the Wrinkled Peach Mushroom, <i>Rhodotus palmatus</i>

Abstract

Seven previously unknown sesquiterpenoids and norsesquiterpenoids, rhodocoranes F–L (1–7), were isolated from the fermentation broth of the basidiomycete Rhodotus palmatus. Their structures were elucidated utilizing 1D and 2D NMR techniques as well as HRESIMS; they are unusual noracorane, spiro[4.4]nonene, and acorane-type sesquiterpenoids. They include the first naturally occurring cyclopentylidenefuranones (3–5) and the new tricyclic scaffold of 7. Metabolites 1–7 exhibited a general mild antimycotic activity, while 1–3 also displayed cytotoxic effects.