A genome-wide transcriptomic analysis of protein-coding genes in human blood cells

TLDR

Blood is the main source for molecular analyses and a target for therapies, underscoring the need for comprehensive molecular maps of its constituent cells. The study aims to perform a genome‑wide transcriptomic analysis of protein‑coding genes in sorted blood immune cell populations to characterize gene expression across blood cell types. The authors performed transcriptomic profiling of sorted blood immune cell populations to quantify protein‑coding gene expression. All data are presented in an interactive, open‑access Blood Atlas integrated with expression profiles across all major tissues, enabling genome‑wide exploration of expression across immune cells and tissues.

Abstract

Blood is the predominant source for molecular analyses in humans, both in clinical and research settings. It is the target for many therapeutic strategies, emphasizing the need for comprehensive molecular maps of the cells constituting human blood. In this study, we performed a genome-wide transcriptomic analysis of protein-coding genes in sorted blood immune cell populations to characterize the expression levels of each individual gene across the blood cell types. All data are presented in an interactive, open-access Blood Atlas as part of the Human Protein Atlas and are integrated with expression profiles across all major tissues to provide spatial classification of all protein-coding genes. This allows for a genome-wide exploration of the expression profiles across human immune cell populations and all major human tissues and organs.