Drug Delivery Systems Based on Poly(2‐Oxazoline)s and Poly(2‐Oxazine)s

Abstract

Abstract Poly(2‐oxazoline)s (PAOx) represent an established class of polymer materials with a wide range of applications. In contrast, the homologous poly(2‐oxazine)s (PAOzi) are only gaining increasing attention in the past years. Despite their high synthetic modularity and excellent biological properties, reports describing their use as a platform for construction of drug delivery systems are still relatively sparse. In this report, an overview of the recent progress in the field of drug delivery systems based on PAOx and PAOzi polymers is provided and a comparison is made with systems based on other polymer carriers, particularly poly(ethylene glycol) (PEG) and poly( N ‐hydroxypropylmethacrylamide) (PHPMA). The emerging potential of PAOx and PAOzi is highlighted in the context of current polymer therapeutics research.