Concepedia

Gentiopicroside (GENT) protects against sepsis induced by lipopolysaccharide (LPS) through the NF-κB signaling pathway

Qiong Wang, Xin Zhou, Long Yang, Maocai Luo, Lei Han, Yao Lu, Qi Shi, Yongjun Wang, Qianqian Liang

Annals of Translational Medicine · 2019 · 37 citations · 31 references

Open access

Abstract

GENT prevented LPS/IFN-γ-induced inflammatory cytokine production by macrophages through the NF-κB signaling pathway <i>in vitro</i> and protected against the endotoxin shock induced by LPS <i>in vivo</i>.

References

31

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R.P. Dellinger, Mitchell M. Levy, Andrew Rhodes et al. · Intensive Care Medicine · 2013 · 7.3K citations · Full text

Trauma Resuscitation, Critical Care Management, Severe Sepsis +10

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R. Phillip Dellinger, Mitchell M. Levy, Jean Carlet et al. · Intensive Care Medicine · 2007 · 4.9K citations · Full text

Critical Care Management, Trauma Resuscitation, Severe Sepsis +9

F4/80, a monoclonal antibody directed specifically against the mouse macrophage

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The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: macrophages of endocrine organs.

David Hume, DMG Halpin, H. M. Charlton et al. · Proceedings of the National Academy of Sciences · 1984 · 278 citations · Full text

Macrophage-specific Antigen F4/80, Immunohistochemical Localization, Laboratory Immunology +22