Journal of Virology · 2019 · 40 citations · 60 references
Life SciencesImmunologyInfectious DiseasesAdaptive ImmunityVaccine ImmunologyVaccinologyCell-mediated ImmunityHelper T Cell SubsetsHumoral Immune ResponsesHumoral ImmunityImmune Response To VaccinationT Cell BiologyCd4 Positive T Cell ResponsesCd4+ T Helper Cell ResponsesFollicular Helper T Cell RegulationFollicular Helper T Cell ResponsesFollicular Helper T CellsT Follicular Helper CellsT-cell Immune ResponsesT-cell Mediated Responses
The results of the RV144 trial demonstrated that vaccination could prevent HIV transmission in humans and that longevity of anti-Env antibodies may be key to this protection. Efforts to improve upon the prime-boost vaccine regimen used in RV144 have indicated that booster immunizations can increase serum anti-Env antibody titers but only transiently. Poor antibody durability hampers efforts to develop an effective HIV-1 vaccine. This study was designed to identify the specific elements involved in the immunological mechanism necessary to produce robust HIV-1-specific antibodies in rhesus macaques. By clearly defining immune-mediated pathways that improve the magnitude and functionality of the anti-HIV-1 antibody response, we will have the foundation necessary for the rational development of an HIV-1 vaccine.
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