iScience · 2019 · 42 citations · 51 references
MedicineAnesthesiologyNeuroscienceAnesthesiaGeneral AnesthesiaNeuropharmacologyAnesthetic PharmacologyGeneral Anesthetic AgentsIon Channel PharmacologyMembrane ElectrophysiologyRodent AnesthesiaSodium Channel BiophysicsAnesthetic PhysiologyIsoflurane AnesthesiaSodium Channel ConductanceSodium Channel PhysiologySpontaneous Firing RateVoltage-gated ChannelsVoltage-gated Sodium Channel ModulationVoltage-gated Sodium Channels
currents and action potential amplitudes. Isoflurane at sub-anesthetic concentrations depolarized resting membrane potential (RMP) of neurons, whereas hyperpolarized the RMP at anesthetic concentrations. Isoflurane at low concentrations induced hyperactivity in vivo, which was diminished in NALCN knockdown mice. In conclusion, enhancement of NALCN by isoflurane contributes to its bidirectional modulation of neuronal excitability and the hyperactivity during induction.
51
Inhalational anesthetics activate two-pore-domain background K+ channels
Amanda Patel, Éric Honoré, Florian Lesage et al. · Nature Neuroscience · 1999 · 644 citations
Boxun Lu, Yanhua Su, Sudipto Das et al. · Cell · 2007 · 387 citations · Full text