Copper oxide, ionic liquid and Mn(III) Salen modified carbon paste electrode as selective electrochemical sensor for determination of droxidopa in the presence of carbidopa

Abstract

A novel electrochemical sensor for the selective and sensitive detection of droxidopa in presence of carbidopa at physiological pH was developed by the bulk modification of carbon paste electrode (CPE) with copper oxide (CuO), ionic liquid and Mn (III) salen (CuO-IL-MS/CPE). Large peak separation, good sensitivity and stability allow this modified electrode to analyze droxidopa individually and in the presence of carbidopa. Applying differential pulse voltammetry (DPV), a linear dynamic range of 0.5-600.0 µM with detection limit of 0.2 µM was obtained for droxidopa. Finally, the proposed method was applied to the determination of droxidopa and carbidopa in real samples.