Concepedia

MiR-23~27~24–mediated control of humoral immunity reveals a TOX-driven regulatory circuit in follicular helper T cell differentiation

Cheng-Jang Wu, Sunglim Cho, Hsi‐Yuan Huang, Chun‐Hao Lu, Jasmin Russ, Leilani O. Cruz, Flávia Franco da Cunha, Mei‐Chi Chen, Ling-Li Lin, Lindsey Warner,

Science Advances · 2019 · 35 citations · 35 references

DOIFull text

Open access

Concepts

Abstract

miR-23~27~24 regulates T FH cells through targeting multiple genes including TOX, a key transcription factor for T FH cell biology.

References

35

Genome engineering using the CRISPR-Cas9 system

F. Ann Ran, Patrick D. Hsu, Jason Wright et al. · Nature Protocols · 2013 · 11.7K citations · Full text

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Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

Robert J. Johnston, Amanda C. Poholek, Daniel DiToro et al. · Science · 2009 · 1.6K citations

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Bcl6 Mediates the Development of T Follicular Helper Cells

Roza Nurieva, Yeonseok Chung, Gustavo Martínez et al. · Science · 2009 · 1.5K citations · Full text

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The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment

Di Yu, Sudha Rao, Louis M. Tsai et al. · Immunity · 2009 · 1.2K citations · Full text

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ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6

Youn Soo Choi, Robin Kageyama, Danelle S. Eto et al. · Immunity · 2011 · 927 citations · Full text

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