Licocoumarone induces BxPC-3 pancreatic adenocarcinoma cell death by inhibiting DYRK1A

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

Siân Jones, D. Williams Parsons, Jimmy Lin et al. · Science · 2008 · 4K citations · Full text

Medicine, Genetics, Oncology +12

Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome

K. E. Wisniewski, Henryk M. Wı́sniewski, G. Y. Wen · Annals of Neurology · 1985 · 1.2K citations

Medicine, Neurology, Neuroscience +16

The development of the pathologic changes of Alzheimer's disease and senile dementia in patients with Down's syndrome.

P. C. Burger, F. Stephen Vogel · PubMed · 1973 · 344 citations

Medicine, Neurology, Neuroscience +14

PRESENILE DEMENTIA AND ALZHEIMER'S DISEASE IN MONGOLISM

MARY I. OLSON, Cheng‐Mei Shaw · Brain · 1969 · 291 citations

Medicine, Neurology, Neuroscience +10

Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A

Yasushi Ogawa, Yosuke Nonaka, Toshiyasu Goto et al. · Nature Communications · 2010 · 270 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +12