Controlled Release of Vancomycin and Tigecycline from an Orthopaedic Implant Coating Prevents <i>Staphylococcus aureus</i> Infection in an Open Fracture Animal Model

Abstract

Vancomycin and tigecycline can be encapsulated in a polymer coating and released over time to maintain therapeutic levels during the perioperative period. Our results suggest that antibiotic coatings can be used to prevent implant infection and osteomyelitis in the setting of open fracture. This novel open fracture mouse model can be used as a powerful <i>in vivo</i> preclinical tool to evaluate and optimize the treatment of open fractures before further studies in humans.