A Multifunctional Nanocomposite Hydrogel for Endoscopic Tracking and Manipulation

Abstract

Herein, the fabrication of multi‐responsive and hierarchically organized nanomaterial using core‐shell SrF 2 upconverting nanoparticles, doped with Yb 3+ , Tm 3+ , Nd 3+ incorporated into gelatin methacryloyl matrix, is reported. Upon 800 nm excitation, deep monitoring of 3D‐printed constructs is demonstrated. Addition of magnetic self‐assembly of iron oxide nanoparticles within the hydrogel provides anisotropic structuration from the nano‐ to the macro‐scale and magnetic responsiveness permitting remote manipulation. The present study provides a new strategy for the fabrication of a novel highly organized multi‐responsive material using additive manufacturing, which can have important implications in biomedicine.