Concepedia

Differences in PD-L1–Expressing Macrophages and Immune Microenvironment in Testicular Germ Cell Tumors

Sam Sadigh, Sahar J. Farahani, Abhishek Shah, David J. Vaughn, Priti Lal

American Journal of Clinical Pathology · 2019 · 27 citations · 20 references

DOI

Abstract

Robust PD-L1+ TAMs are significantly expanded in seminomas compared with NSGCTs. Among all GCTs, only choriocarcinoma cells reveal true positivity for PD-L1. These findings expand the realm of potentially targeted treatments for GCTs.

References

20

Cancer statistics, 2018

Rebecca L. Siegel, Kimberly D. Miller, Ahmedin Jemal · CA A Cancer Journal for Clinicians · 2018 · 16.8K citations · Full text

High-Dose Chemotherapy and Stem-Cell Rescue for Metastatic Germ-Cell Tumors

Lawrence H. Einhorn, Stephen D. Williams, Amy R. Chamness et al. · New England Journal of Medicine · 2007 · 487 citations · Full text

Paclitaxel, Ifosfamide, and Cisplatin Second-Line Therapy for Patients With Relapsed Testicular Germ Cell Cancer

Robert J. Motzer, Joel Sheinfeld, Madhu Mazumdar et al. · Journal of Clinical Oncology · 2000 · 252 citations

PD-L1 Expression in Human Placentas and Gestational Trophoblastic Diseases

Emanuela Veras, Robert J. Kurman, Tian‐Li Wang et al. · International Journal of Gynecological Pathology · 2016 · 187 citations

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Phase II trial of pembrolizumab in patients with platinum refractory germ-cell tumors: a Hoosier Cancer Research Network Study GU14-206

Nabil Adra, Lawrence H. Einhorn, Sandra K. Althouse et al. · Annals of Oncology · 2017 · 185 citations

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