PubMed · 2018 · 42 citations · 23 references
Open access
MedicineOncologyPharmacologyChemotherapyGene ExpressionMolecular OncologyCancer EpigeneticsCancer ProgressionColorectal CancerMicrorna-mediated RegulationNoncoding Rna In CancerTumor Suppressor GenesCancer-related Noncoding Rna FunctionMicrorna EpigeneticsMicrorna Function In CancerMicrorna In CancerMicrorna ModulationMicrorna Regulation In CancerMicrorna-mediated Pathway RegulationMicrorna-mediated Resistance
. We further demonstrated that the tumor suppressive role of miR-26b was mediated by negatively regulating P-glycoprotein (Pgp) protein expression. Furthermore, studies of colorectal cancer specimens indicated that the expression of miR-26b and Pgp had inverse correlation. Importantly, we found that CpG islands in the miR-26b promoter region were hypermethylated in 5-FU resistant cells. Our study is the first to identify the tumor suppressive role of over-expressed miR-26b in chemo-sensitivity. Identification of a novel miRNA-mediated pathway that regulates chemo-sensitivity in colorectal cancer will facilitate the development of novel therapeutic strategies in the future.
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