Chemical constituents from <i>Artemisia vulgaris</i> and their antiausterity activities against the PANC-1 human pancreatic cancer cell line

Abstract

The 70% ethanolic extract of <i>Artemisia vulgaris</i> showed preferential cytotoxicity against PANC-1 human pancreatic cancer cells under a nutrient-deprived condition with PC₅₀ 12.5 μg/mL. A phytochemical investigation of this extract yielded a new bicyclic [4:3:0] sesquiterpene named (+)-vulgaric acid (<b>1</b>), together with eight previously reported compounds. The structural elucidation of <b>1</b> was achieved by HRFABMS and NMR analysis. The absolute configuration of <b>1</b> was deduced by computational calculations of ECD data. All isolated compounds were tested for preferential cytotoxicity against PANC-1 cells, and apigenin (<b>3</b>) showed the strongest activity with PC₅₀ 30.7 μM.