Electrochemical Synthesis of 1,2,4‐Thiadiazoles through Intermolecular Dehydrogenative S‐N Coupling

Abstract

Abstract An electrochemical intermolecular dehydrogenative coupling reaction of isothiocyanates with 2‐aminopyridines/amidines was developed. Using n ‐Bu 4 NI as the catalyst and electrolyte, 1,2,4‐thiadiazoles and pyrido‐fused 1,2,4‐thiadiazoles were readily accessed with good to excellent efficiency under the undivided electrolysis conditions. This electrochemical approach obviates the use of external oxidants and transition‐metal catalysts. magnified image