Agelanemoechine, a Dimeric Bromopyrrole Alkaloid with a Pro-Angiogenic Effect from the South China Sea Sponge <i>Agelas nemoechinata</i>

Abstract

One new dimeric bromopyrrole alkaloid, agelanemoechine, with an unprecedented imidazo [1,5-<i>a</i>] azepin nucleus together with one known dimeric bromopyrrole alkaloid sceptrin were isolated from the marine sponge <i>Agelas nemoechinata</i>. The structure elucidation and absolute configuration assignments were determined by extensive spectroscopic analyses and the comparison of experimental and calculated ECD. Agelanemoechine showed strong pro-angiogenic activity in zebrafish.