Concepedia

Effect of Polydeoxyribonucleotide on Lipopolysaccharide and Sevoflurane-Induced Postoperative Cognitive dysfunction in Human Neuronal SH-SY5Y Cells

Hyungmo Jeong, Jun-Young Chung, Il‐Gyu Ko, Sang‐Hoon Kim, Jun‐Jang Jin, Lakkyong Hwang, Eun-Jin Moon, Bong-Jae Lee, Jae-Woo Yi

International Neurourology Journal · 2019 · 17 citations · 25 references

DOIFull text

Open access

Abstract

PDRN treatment showed a therapeutic effect on the LPS and sevoflurane-induced POCD environment. PDRN was shown to have an excellent therapeutic effect on POCD, not only by promoting rapid anti-inflammatory effects in damaged cells, but also by enhancing the expression of BDNF and VEGF.

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25

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Adenosine A<sub>2A</sub> receptors are required for normal BDNF levels and BDNF‐induced potentiation of synaptic transmission in the mouse hippocampus

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