Overexpression of resistance-related proteins (metallothioneins, glutathione-S-transferase ?, heat shock protein 27, and lung resistance-related protein) in osteosarcoma

Abstract

Inherent overexpression of Hsp27 is independently related to poor outcome in osteosarcoma patients. Overexpression of GST pi, Hsp27, and LRP at surgery might be associated with failure of preoperative chemotherapy. Control of the expression of these proteins may improve the outcome for patients with osteosarcoma.