Association Analysis of 14 Candidate Gene Polymorphism with Depression and Stress among Gestational Diabetes Mellitus

Abstract

The association of candidate genes and psychological symptoms of depression, anxiety, and stress among women with gestational diabetes mellitus (GDM) in Malaysia was determined in this study, followed by the determination of their odds of getting psychological symptoms, adjusted for socio-demographical background, maternal, and clinical characteristics. Single nucleotide polymorphisms (SNPs) recorded a significant association between SNP of <i>EPHX2</i> (rs17466684) and depression symptoms (AOR = 7.854, 95% CI = 1.330-46.360) and stress symptoms (AOR = 7.664, 95% CI = 1.579-37.197). Associations were also observed between stress symptoms and SNP of <i>OXTR</i> (rs53576) and (AOR = 2.981, 95% CI = 1.058-8.402) and SNP of <i>NRG1</i> (rs2919375) (AOR = 9.894, 95% CI = 1.159-84.427). The SNP of <i>EPHX2</i> (rs17466684) gene polymorphism is associated with depression symptoms among Malaysian women with GDM. SNP of <i>EPHX2</i> (rs17466684), <i>OXTR</i> (rs53576) and <i>NRG1</i> (rs2919375) are also associated with stress symptoms.