Concepedia

Polyamine-Based Pt(IV) Prodrugs as Substrates for Polyamine Transporters Preferentially Accumulate in Cancer Metastases as DNA and Polyamine Metabolism Dual-Targeted Antimetastatic Agents

Hanfang Liu, Jing Ma, Yingguang Li, Kexin Yue, Linrong Li, Zhuoqing Xi, Xiao Zhang, Jianing Liu, Kai Feng, Qi Ma,

Journal of Medicinal Chemistry · 2019 · 35 citations · 47 references

DOI

Concepts

Abstract

-induced tumor metastasis. Our study implies a promising strategy for the design of platinum drugs for the treatment of terminal cancer.

References

47

The status of platinum anticancer drugs in the clinic and in clinical trials

Nial Wheate, Shonagh Walker, Gemma E. Craig et al. · Dalton Transactions · 2010 · 1.6K citations

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Activation of <i>SAT1</i> engages polyamine metabolism with p53-mediated ferroptotic responses

Yang Ou, Shang-Jui Wang, Dawei Li et al. · Proceedings of the National Academy of Sciences · 2016 · 748 citations · Full text

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Targeted photoredox catalysis in cancer cells

Huaiyi Huang, Samya Banerjee, Kangqiang Qiu et al. · Nature Chemistry · 2019 · 524 citations · Full text

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Polyvalent Oligonucleotide Gold Nanoparticle Conjugates as Delivery Vehicles for Platinum(IV) Warheads

Shanta Dhar, Weston L. Daniel, David A. Giljohann et al. · Journal of the American Chemical Society · 2009 · 509 citations · Full text

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Pt(IV) Prodrugs Designed to Bind Non-Covalently to Human Serum Albumin for Drug Delivery

Yao‐Rong Zheng, Kogularamanan Suntharalingam, Timothy C. Johnstone et al. · Journal of the American Chemical Society · 2014 · 435 citations · Full text

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