Enabling P-glycoprotein inhibition in multidrug resistant cancer through the reverse targeting of a quinidine-PEG conjugate

Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells.

John M. Zamora, Homer L. Pearce, William T. Beck · Molecular Pharmacology · 1988 · 414 citations

Medicine, Oncology, Pharmacology +15

Inhibition of P-Glycoprotein–Mediated Drug Transport

Martin F. Fromm, Richard B. Kim, C. Michael Stein et al. · Circulation · 1999 · 400 citations

Medicine, Pharmacokinetics, Pharmacology +16

Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells.

Yossef Raviv, Harvey B. Pollard, Edward Bruggemann et al. · Journal of Biological Chemistry · 1990 · 392 citations · Full text

Medicine, Biochemistry, Pharmacology +16

Mechanism of Pluronic Effect on P-Glycoprotein Efflux System in Blood-Brain Barrier: Contributions of Energy Depletion and Membrane Fluidization

Elena V. Batrakova, Shu Li, Valery Yu. Alakhov et al. · Journal of Pharmacology and Experimental Therapeutics · 2001 · 291 citations

Medicine, Biochemistry, Pharmacology +17

Optimal Structure Requirements for Pluronic Block Copolymers in Modifying P-glycoprotein Drug Efflux Transporter Activity in Bovine Brain Microvessel Endothelial Cells

Elena V. Batrakova, Shu Li, Valery Yu. Alakhov et al. · Journal of Pharmacology and Experimental Therapeutics · 2003 · 264 citations

Medicine, Biochemistry, Pharmacology +17