Journal of Cellular Biochemistry · 2019 · 20 citations · 16 references
Life SciencesGeneticsMolecular GeneticsGenetic EpidemiologyHuman GeneticsMedical GeneticsGenetic DisordersGenotype-phenotype Association AnalysisHaplotype AnalysisMultiple MyelomaReceptor PolymorphismsVitamin D DisordersDisease-specific Risk AllelesGenetic PolymorphismsHigh-risk Multiple MyelomaLinkage Disequilibrium AnalysisLinkage Disequilibrium PatternsMyeloma PathogenesisVitamin D Receptor GeneticsVitamin D Receptors
OBJECTIVES: The aim of this study was to explore the Vitamin D receptor (VDR) gene polymorphism and its association with multiple myeloma (MM) development. METHODS: The peripheral blood of 40 MM cases and 84 healthy controls were collected. Polymerase chain reaction (PCR) and DNA sequencing were applied to detect VDR gene polymorphism (including: FokI, BsmI, ApaI, and TaqI). SHESIS biological information software was used to analyze genotypes, alleles, linkage disequilibrium (LD), haplotype distribution, and their association with MM. RESULTS: Compared with controls, the MM group had a significantly higher frequency of the A allele in BsmI site (8.7% vs 2.4%) and C allele in the TaqI site (10.5% vs 3.6%). These two alleles were closely associated with an increased risk of MM (P = .025; P = .030). The highly rare genotypes (BsmI-AA and TaqI-CC) were found in one patient with MM. CONCLUSION: VDR gene polymorphisms may be a molecular marker of MM risk.
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Prediction of bone density from vitamin D receptor alleles
Nigel A. Morrison, Jian Qi, Akifumi Tokita et al. · Nature · 1994 · 1.9K citations