Concepedia

Shenkang injection, a modern preparation of Chinese patent medicine, diminishes tubulointerstitial fibrosis in obstructive nephropathy via targeting pericyte-myofibroblast transition.

Yinglu Liu, Ge Shi, Hong-Yun Yee, Wenwen Wang, Wen-Bei Han, Bu-Hui Liu, Wei Wu, Yue Tu, Qian Ma, Dongqin Huo,

PubMed · 2019 · 17 citations · 21 references

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Concepts

Abstract

. In addition, the high dose of SKI, superior to imatinib, specifically blocked PMT through inhibiting the activation of PDGFR and VEGFR signaling in the kidneys of the UUO model rats. Overall, these findings may further suggest that targeting PMT can provide new strategies for ON treatment.

References

21

Pericytes and Perivascular Fibroblasts Are the Primary Source of Collagen-Producing Cells in Obstructive Fibrosis of the Kidney

Shuei‐Liong Lin, Tatiana Kisseleva, David A. Brenner et al. · American Journal Of Pathology · 2008 · 839 citations · Full text

, , +17

Platelet-derived growth factor receptor signaling activates pericyte–myofibroblast transition in obstructive and post-ischemic kidney fibrosis

Yi‐Ting Chen, Fan‐Chi Chang, Ching-Fang Wu et al. · Kidney International · 2011 · 335 citations · Full text

, , +16

Targeting Endothelium-Pericyte Cross Talk by Inhibiting VEGF Receptor Signaling Attenuates Kidney Microvascular Rarefaction and Fibrosis

Shuei‐Liong Lin, Fan‐Chi Chang, Claudia Schrimpf et al. · American Journal Of Pathology · 2011 · 265 citations · Full text

, , +12

Transforming Growth Factor β-1 Stimulates Profibrotic Epithelial Signaling to Activate Pericyte-Myofibroblast Transition in Obstructive Kidney Fibrosis

Ching-Fang Wu, Wen‐Chih Chiang, Chun‐Fu Lai et al. · American Journal Of Pathology · 2012 · 247 citations · Full text

, , +17

Pericyte TIMP3 and ADAMTS1 Modulate Vascular Stability after Kidney Injury

Claudia Schrimpf, Cuiyan Xin, Gabriella Campanholle et al. · Journal of the American Society of Nephrology · 2012 · 206 citations · Full text

, , +13