Long non-coding RNA MEG3 promotes cerebral ischemia-reperfusion injury through increasing pyroptosis by targeting miR-485/AIM2 axis

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Jianjin Shi, Yue Zhao, Kun Wang et al. · Nature · 2015 · 6.5K citations

Life Sciences, Immunology, Molecular Biology +14

The Inflammasome

Fabio Martinon, Kimberly Burns, Jürg Tschopp · Molecular Cell · 2002 · 6K citations · Full text

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

Vijay Rathinam, Zhaozhao Jiang, Stephen N. Waggoner et al. · Nature Immunology · 2010 · 1.3K citations · Full text

Life Sciences, Immunology, Microbiology +16

Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke

David Y. Fann, Silvia Manzanero, Mathias Gelderblom et al. · Cell Death and Disease · 2013 · 490 citations · Full text

Life Sciences, Neurology, Neuroscience +17

A Pituitary-Derived MEG3 Isoform Functions as a Growth Suppressor in Tumor Cells

Xun Zhang, Yunli Zhou, Kshama Mehta et al. · The Journal of Clinical Endocrinology & Metabolism · 2003 · 448 citations · Full text

Medicine, Genetics, Oncology +16