PI3K/AKT pathway genetic alterations and dysregulation of expression in bladder cancer. - Concepedia

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PI3K/AKT pathway genetic alterations and dysregulation of expression in bladder cancer.

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References

2019

Year

Stefanos Kachrilas, Athanasios Dellis, Athanasios Papatsoris, Socratis Avgeris, Dimitra Anastasiou, Ariana Gavriil, Maria Horti, Sofia Tseleni‐Balafouta, Konstantinos Livadas, Dimitrios J. Stravopodis,

Abstract

PI3K/AKT pathway activation is crucial for bladder cancer initiation and progression. In this context, PIK3CA, p-AKT and nuclear PTEN could be used along with other biomarkers for prognosis and selection of appropriate therapy in the clinical management of bladder cancer.