Cancer-Associated Fibroblasts Promote Angiogenesis of Hepatocellular Carcinoma by <i>VEGF</i>-Mediated <i>EZH2/VASH1</i> Pathway

Abstract

Our study identified the relationship between cancer-associated fibroblasts and enhancer of zeste homolog-2 and confirmed the pivotal role of cancer-associated fibroblasts in angiogenesis of hepatocellular carcinoma. Cancer-associated fibroblasts promote angiogenesis of hepatocellular carcinoma by vascular endothelial growth factor-mediated enhancer of zeste homolog-2/vasohibin 1 pathway and may be a potentially useful therapeutic target for hepatocellular carcinoma.