Life SciencesMolecular BiologyPhysiologyCell SignalingCircadian RhythmsSignal TransductionCircadian Activity PatternsCircadian Clock MechanismsCircadian Gene ExpressionCircadian Molecular MechanismsCircadian PhysiologySuprachiasmatic NucleusHypothalamic FunctionLight-dark Cycle EntrainmentLight-induced Clock SignalingMammalian Circadian TimingMaster Clock RegulationPhosphorylation Of Clock ProteinsProtein Phosphorylation CascadesSuprachiasmatic Nucleus Clockwork
). This circadian gating of the synchronizing effect of light is dependent on the specific activation of signal transduction pathways involving several kinases acting on protein effectors. Protein phosphorylation is also an important regulatory mechanism essential for the generation and maintenance of circadian rhythms and plays a crucial role in the degradation and the appropriate turnover of PER proteins. In this work, we review the role of the main kinases implicated in the function of the master clock, with emphasis in those involved in circadian photic entrainment.
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An h <i>Per2</i> Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome
Kong Leong Toh, Christopher R. Jones, Yan He et al. · Science · 2001 · 1.5K citations
Posttranslational Mechanisms Regulate the Mammalian Circadian Clock
Choogon Lee, Jean‐Pierre Etchegaray, Felino R. Cagampang et al. · Cell · 2001 · 1.2K citations · Full text
Life Sciences, Biochemistry, Biology +14