Studies on Antihemorrhagic Principles in the Crude Drugs for Hemostatics. II. On Antihemorrhagic Principle in Sanchi Ginseng Radix

Abstract

We have previously communicated the hemostatic activity in the crude drugs employed for hemostatics. This communication is one of the studies on isolation of an active substance, a hemostatic component in Sanchi Gingseng Radix. An active principle which was designated as "dencichine" was isolated by suitable combination of counter current distribution, gelfiltration (Sephadex LH-20) and ionexchange chromatography (CM-Sephadex C-25) from H2O-extract. Dencichine was identified as β-N-oxalo-L-α, β-diaminopropionic acid (neurotoxin).